RSPT 2317 Anti-Infectives & Antibiotics AEROSOLIZED ANTI-INFECTIVE AGENTS Generic name: Pentamidine isethionate Brand name: NebuPent Mode of action: Pentamidine is an antiprotozoal, active against Pneumocystis carinii, the causative organism of Pneumocystis carinii pneumonia (PCP) in patients
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Catheter-related infections and associated septicemia.
Communications to the Editor not have active Pneumocystis carinii pneumonia (PCP). All of these patients had a history of single or recurrent episodes of PCP and were receiving aerosolized pentamidine isethionate as prophylaxis against recurrence of PCP It was suspected that the pneumothoraces were caused by coughing due to the irritative effect of pentamidine therapy on the airways superimpose...
متن کاملBiological profile and response to anti-pneumocystis agents of Pneumocystis carinii in cell culture.
Although the growth characteristics of Pneumocystis carinii have been described in several cell culture systems, the response of this organism to the drugs of choice, trimethoprim-sulfamethoxazole and pentamidine isethionate, have not been described in vitro. The effect of various concentrations of drugs against P. carinii on the growth of this potentially hazardous opportunistic organism as we...
متن کاملLobar pentamidine levels and Pneumocystis carinii pneumonia following aerosolized pentamidine.
Recent studies have suggested that failure of pentamidine prophylaxis against Pneumocystis carinii pneumonia (PCP) may be due to reduced deposition of pentamidine in the upper lobes. In this study, we performed bronchoalveolar lavage from the apical segment of the upper lobe and the middle lobe in 51 HIV-positive patients, all of whom were receiving prophylaxis with aerosolized pentamidine, who...
متن کاملTreatment and prophylaxis of Pneumocystis carinii pneumonia.
Trimethoprim-sulfamethoxazole and parenteral pentamidine isethionate are effective in 60 to 80 per cent of AIDS patients with pneumocystis pneumonia. Adverse reactions are frequent with both agents, but because the adverse reactions are less severe with trimethoprim-sulfamethoxazole, this agent is the drug of choice for patients who are not known to be intolerant of it. The recommended duration...
متن کاملSuccessful treatment with aerosolized pentamidine of Pneumocystis carinii pneumonia in rats.
We examined both the therapeutic efficacy and tissue distribution of aerosolized pentamidine in immunosuppressed rats with Pneumocystis carinii pneumonia. In rats immunosuppressed by 5 weeks of pretreatment with dexamethasone, a 2-week course of 5 mg of aerosolized pentamidine per kg per day, administered free or encapsulated in the drug carrier system (liposomes), eradicated P. carinii pneumon...
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